They all have the same potential issue....
Aye, which is why we need more data
Causal relation appears possible, but evidence still indicates it's extremely rare
www.medpagetoday.com
One hypothesis is that the mRNA vaccines (Pfizer, Moderna) and those using adenoviruses (AstraZeneca, Johnson & Johnson) could induce synthesis of the COVID spike protein within platelets, which may then trigger autoimmune reactions against platelets, Hamid Merchant, PhD, of the University of Huddersfield in England, wrote in a
letter to The BMJ.
"COVID genetic vaccines may have a direct role in spurring an autoimmune response against platelets that may clinically manifest in thrombocytopenia, hemorrhage, and blood clots. Clotting risks may be equally possible with all genetic COVID vaccines, and may not be limited only with the AstraZeneca/Oxford vaccine," he told
MedPage Today.
Pruthi said ITP related to vaccination is probably a separate process involving a different autoantibody than the HIT reaction linked to the European CVST cases. The important point is that healthcare providers recognize the possibility that platelet factor 4 antibody could be involved in very rare cases of CVST after vaccination for COVID-19.
"Generally when patients develop CVST, the first thing you do is give them heparin. In this situation, that would be the worst thing to do. You would need to avoid heparin and use a different nonheparin anticoagulant," he said. "Hence the importance of making the diagnosis. Providers need to be vigilant to this phenomenon, to make sure they get the right tests, diagnose it quickly, and consult a coagulation expert."
endpts.com
