Current Affairs Coronavirus Thread - Serious stuff !!!

[Deckard2049]

I just think when we are "all in this together" and all ages groups have made sacrifices over the last 12 months it shouldn't be screw the young ones you aint getting a jab (I say this as having a healthy 33 year old mate who was hospitalised with blood clots in his lungs from Covid a few months back).

If the vaccines supply increase by all means but its suicide opening up in June with the under 30's still not given even 1 jab.

Imagine a saturday night in Concert Square or in major cities without restrictions man.

I think the issue is how our supply is broken down. It seems like we have a boatload of AZ but that has obviously been restricted for under 30’s and I even saw some reports this week saying it will be used minimally for under 40’s, especially 35 and below. If that’s the case then we need a lot of Pfizer and perhaps Moderna to really ramp up our first doses as we move down the age groups.

I know amongst my friends we were hoping that the one shot jab would be available but I know that had some issues in the US similar to what AZ had in regards to clots and I don’t even think it’s been fully approved here anyway.

I do agree with you though, we could do with a lot more people having their first doses before we really open up much further.

 

[Neiler]

@Neiler small study and a preprint but encouraging. Would ideally like to see comparison of symptoms/hospitalization rates as well.

Delaying a COVID vaccine’s second dose boosts immune response

Older people who waited 11–12 weeks for their second jab had higher peak antibody levels than did those who waited only 3 weeks.

www.nature.com

To determine whether the delay paid off, Amirthalingam and her colleagues studied 175 vaccine recipients older than 80 who received their second dose of the Pfizer vaccine either 3 weeks or 11–12 weeks after the first dose. The team measured recipients’ levels of antibodies against the SARS-CoV-2 spike protein and assessed how immune cells called T cells, which can help to maintain antibody levels over time, responded to vaccination.

Peak antibody levels were 3.5 times higher in those who waited 12 weeks for their booster shot than were those in people who waited only 3 weeks. Peak T-cell response was lower in those with the extended interval. But this did not cause antibody levels to decline more quickly over the nine weeks after the booster shot.

Thanks mate. Its an interesting study, it certainly back the U.K.S decision, in fact 3.5% better antibody response - quite amazing. I’d be curious on the T-Cell response long term, as we know that’s key to longevity when antibodies fade. I read an interpreted version of this earlier, that said T-Cells were lower after 12 weeks compared to 3/4, but then the both became similar after 16 weeks later.

Either way, though not peer reviewed this study should help us get the most our of our vaccines, its something we should be constantly looking at trying to evolve.

 

[coollino]

Well, the pub was absolutely packed tonight, obviously no one inside, but we must have had 150-200 outside. I think we should just keep the inside closed tbh.....

I said that to you the other month and you didn't agree!

Good to hear it's busy.
My local is currently staying shut until the June date, they are mainly inside and said the whole process felt so impersonal last time they opened.

 

[COYBL25]

I just think when we are "all in this together" and all ages groups have made sacrifices over the last 12 months it shouldn't be screw the young ones you aint getting a jab (I say this as having a healthy 33 year old mate who was hospitalised with blood clots in his lungs from Covid a few months back).

If the vaccines supply increase by all means but its suicide opening up in June with the under 30's still not given even 1 jab.

Imagine a saturday night in Concert Square or in major cities without restrictions man.

Think the Indian virus has blind sided them mate, as the vaccine roll out was targeted according to age related risk.

It’s still early days yet and the spacing out of the opening up was designed for something just like this - to act as a buffer and also give them time to act accordingly if need be.

It’s not all doom and gloom, as it doesn’t look like it’s putting people in hosy / killing people, so the vaccines are doing their job.

My lads is mates with a couple of lads who got to a school in Crosby ( teenagers ) who’ve got it and from what they’re saying to him, it’s like a nasty head cold.

 

[Neiler]

If the Indian variant is as transmissible as they are suggesting it fairly likely it will become the dominant variant.

Looking at the U.K. briefing tonight, they know it too.

We’ve 40 odd cases over here. .1 & .2

Let’s hope our vaccines do their business.

 

[LinekersLegs]

I think the issue is how our supply is broken down. It seems like we have a boatload of AZ but that has obviously been restricted for under 30’s and I even saw some reports this week saying it will be used minimally for under 40’s, especially 35 and below. If that’s the case then we need a lot of Pfizer and perhaps Moderna to really ramp up our first doses as we move down the age groups.

I know amongst my friends we were hoping that the one shot jab would be available but I know that had some issues in the US similar to what AZ had in regards to clots and I don’t even think it’s been fully approved here anyway.

I do agree with you though, we could do with a lot more people having their first doses before we really open up much further.

Don’t know whether a hold was put on it but JnJ applied for UK approval early March - you’d have thought with 30 million doses on order and both US & EU clearance the process would have gone quicker even if there were some restrictions placed on its usage.

Johnson & Johnson applied for vaccine approval in UK late last week

The UK has already secured 30 million doses of the vaccine.

www.politico.eu

US supply has had problems due to a manufacturing plant issue but the Belgium production is still Ok as far as I am aware

https://www.washingtonpost.com/business/2021/05/13/vaccine-johnson-johnson-shortage/

 

[Neiler]

Don’t know whether a hold was put on it but JnJ applied for UK approval early March - you’d have thought with 30 million doses on order and both US & EU the process would have gone quicker even if there were some restrictions placed on its usage.

Johnson & Johnson applied for vaccine approval in UK late last week

The UK has already secured 30 million doses of the vaccine.

www.politico.eu

US supply has had problems due to a manufacturing plant issue but the Belgium production is still Ok as far as I am aware

https://www.washingtonpost.com/business/2021/05/13/vaccine-johnson-johnson-shortage/

I think the first U.K. J&J order is due in July, on that basis, i think they haven’t needed to rush on authorisation.

 

[LinekersLegs]

 

[Neiler]

This bodes well anecdotally in terms of protection from vaccination.

Any instances in the Sates?

 

[LinekersLegs]

This bodes well anecdotally in terms of protection from vaccination.

Any instances in the Sates?

Yes but so far not as much. Although I don’t feel our measuring is as robust as UK tbh.


One open question I haven’t seen much data on is how much protection previous exposure to wild type/other variants provides.

I feel fairly confident re vaccine’s protection against severe outcomes, especially for fully vaccinated.

 

[Neiler]

Yes but so far not as much. Although I don’t feel our measuring is as robust as UK tbh.


One open question I haven’t seen much data on is how much protection previous exposure to wild type/other variants provides.

I feel fairly confident re vaccine’s protection against severe outcomes, especially for fully vaccinated.

UK are really world leading at sequencing. You wonder if this has/is as prevalent elsewhere and the U.K. are just identifying .

I haven’t seen the data used, but over here anyone with either a history of wild type or mutated is offered just one dose and considered fully vaccinated.

I agree mate I’m also confident in the vaccines for severity, etc, be awful for young people.

 

[LinekersLegs]

 

[LinekersLegs]

 

[LinekersLegs]

I’ve noted anecdotal reports of higher disease severity in younger patients in India, this may be a factor if that is indeed the case.

 

[Paris]

Speaking to my friends in SE Asia, a lot of that is down to incompetent government and a unwillingness on behalf of the population to get vaccinated. The Chinese vaccines arrived months ago but as we've seen from Seychelles, they're completely ineffective and of course there are trust issues there. I'm not sure what we can do about that.