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Those who had an earlier case of Covid typically have stronger side effects to their first dose than those unexposed but on the plus side none of the sode effects seem to last that long
Given preliminary evidence from small studies21, 22, 23 suggesting that reactogenicity is higher among individuals previously infected with SARS-CoV-2, we investigated the extent to which previous SARS-CoV-2 infection (based on self-reported previous positive PCR or lateral flow result) was associated with reports of adverse effects.
Individuals vaccinated with a single dose of BNT162b2 were more likely to report systemic effects if they had a previous SARS-CoV-2 positive test than were those without known past infection (5148 [35·8%] of 14 369 vs 33 007 [12·3%] of 267 734; OR 3·97 [95% CI 3·83–4·12], p<0·0001).
A similar effect was seen for ChAdOx1 nCoV-19 first dose inoculation (7551 [53·1%] of 14 231 with past infection vs 108 922 [32·9%] of 331 049 without past infection; 2·31 [2·23–2·38], p<0·0001; figure 3) and BNT162b2 second dose inoculation (859 [38·2%] of 2251 vs 5357 [20·6%] of 25 956; 2·37 [2·17–2·60], p<0·0001). Local effects were similarly higher in individuals previously infected than in those without known past infection for both vaccines (figure 3). No consistent difference in occurrence of systemic or local adverse effects was observed between individuals who reported a positive test result within the past 6 months and those who reported they received a positive test result at least 6 months ago (figure 3).
