Current Affairs Coronavirus Thread - Serious stuff !!!

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Ignorant to call him a quack, tbh - he is legitimately one of the most influential scientists alive (if you want to waste time disputing this have a google of what h-index means, and then think what it would take to amass one greater than 200).

That's not to say he isn't speaking a giant amount of bolex on covid. He seems to have seen the lack of data and evidence-based decision making in the early days of the pandemic and correctly called it out, but taken an absurdly big position - everyone's wrong I'm right. Which is the diametric opposite of his whole research career, which is all about how bias and insufficient data undermine conclusions and create weak science.
Strangely aggressive start to this but ok. Quack was the wrong word to use and I should have specified I was talking about his stance on covid. I had no idea about his history but I see that he is very respected. I also see that he is chatting utter rubbish about covid and should not be someone that is quoted when defending a position on the pandemic. His stance is dangerous and would have lead to many more deaths if it had been followed
 
We couldn’t have, actually. Even if we’d followed a four week schedule some nations would have been ahead of us regardless.

You seem desperate to view the vaccine rollout negatively, which is a shame.

Well, I said "near the tops of" and not "top of" - and I am right; if we'd used the Pfizer vaccine as authorised and as most other countries are using it, we'd have been around third worldwide in terms of full doses given by mid February or so and probably would have stayed around there.

As for the rest, sorry but that is flat out wrong. My objection to the vaccine rollout in the UK has, consistently, been this Pfizer spacing issue. I've been saying that since they announced it.
 
Interesting analysis of Pfizer's impact on the variants regarding partial / full vaccination:



@Neiler


Just read the study, thanks for posting mate.

Take home is the South African variant, like we thought, can pretty much punch through our first generation vaccines to a different degree depending on the vaccine, it’s Pfizer in this case as Israel is unique as the country is wholly Pfizer vaccinated. Very good indicators though on the Pfizer vaccine and transmissibility.

The South African variant is very worrying if it went the way of the U.K. variant in prevalence or evolved to be as transmissible. It’s why the whole world has closed borders and is quarantining. You couldn't pay me to go on a holiday abroad this year, sheer madness in my opinion.
 
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Just read the study, thanks for posting mate.

Take home is the South African variant, like we thought, can pretty much punch through our first generation vaccines to a different degree depending on the vaccine, it’s Pfizer in this case as Israel is unique as the country is wholly Pfizer vaccinated. Very good indicators though on the Pfizer vaccine and transmissibility.

The South African variant is very worrying if it went the way of the U.K. variant in prevalence or evolved to be as transmissible. It’s why the whole world has closed borders and is quarantining. You couldn't pay me to go on a holiday abroad this year, sheer madness in my opinion.
Did it mention in the article, I wonder, how many took part in the test (couldn't gain access to the full report)? I get the impression not too many.

Also, didn't Israel stick to the 3 week gap between 1st and 2nd jabs of Pfizer? That could be significant (either way) if the SA variant was breaking through after 2 doses.
 
Did it mention in the article, I wonder, how many took part in the test (couldn't gain access to the full report)? I get the impression not too many.

Also, didn't Israel stick to the 3 week gap between 1st and 2nd jabs of Pfizer? That could be significant (either way) if the SA variant was breaking through after 2 doses.

“the researchers examined around 400 members of Clalit Health who tested positive for the virus 14 days or more after receiving the first dose of the vaccine in comparison to 400 unvaccinated people who caught corona, too. The cohorts were matched according to age, sector, gender and more.

The study showed that the South African variant is more likely to break through the vaccine’s protective effect, even after two doses have been administered and more than a week has passed.”

They did mate, they are rolling with the three week intervals. They have a deal with Pfizer that supply won’t drop off until 95% of their population is vaccinated.
 
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Well, I said "near the tops of" and not "top of" - and I am right; if we'd used the Pfizer vaccine as authorised and as most other countries are using it, we'd have been around third worldwide in terms of full doses given by mid February or so and probably would have stayed around there.

As for the rest, sorry but that is flat out wrong. My objection to the vaccine rollout in the UK has, consistently, been this Pfizer spacing issue. I've been saying that since they announced it.

Can you show me the data on this, as I don’t think it’s true.
 
Scientist Katalin Kariko who made the key discovery about RNA that led to the Moderna and Pfizer/BioNTech vaccines. A great story of scientific passion and perseverance.

 
I would think our reduced cases and hospital admissions is all the evidence you would need?
Tbh no, especially given AZ make up the majority of UK vaccinations,

Is it suggestive, yes but we really need more data that as far as I’m aware we don’t have.

My major issues with the change in the Pfizer dosage by the UK (against manufacturers recommendations) wasn’t ao much that it happened, given B1117 was rife it was a calculated gamble. However it wasn’t accompanied by a rigorous data collection exercise of precisely how it impacted outcomes (measuring patients antibody levels, detailed symptom tracking compared to the 3 week gap, death/hospitalization rates for vaccine delayed recipients etc) and that everyone involved wasn’t aware of the greater risk with informed consent.

The UK winged it with Pfizer and as you say it appears to have worked out but honestly it was a pretty half assed approach that makes it hard for any other nation to replicate it in good conscience.

In contrast the delay with AZ was supported by the initial trial results, admittedly those being due to a serendipitous mess up of their trial.
 
Scientist Katalin Kariko who made the key discovery about RNA that led to the Moderna and Pfizer/BioNTech vaccines. A great story of scientific passion and perseverance.

@LinekersLegs posted this yesterday. Incredible story and Dr Kariko should be lauded as a hero. Not just for what she has done for covid but what mRNA can do for other viruses.
 
Tbh no, especially given AZ make up the majority of UK vaccinations,

Is it suggestive, yes but we really need more data that as far as I’m aware we don’t have.

My major issues with the change in the Pfizer dosage by the UK (against manufacturers recommendations) wasn’t ao much that it happened, given B1117 was rife it was a calculated gamble. However it wasn’t accompanied by a rigorous data collection exercise of precisely how it impacted outcomes (measuring patients antibody levels, detailed symptom tracking compared to the 3 week gap, death/hospitalization rates for vaccine delayed recipients etc) and that everyone involved wasn’t aware of the greater risk with informed consent.

The UK winged it with Pfizer and as you say it appears to have worked out but honestly it was a pretty half assed approach that makes it hard for any other nation to replicate it in good conscience.

In contrast the delay with AZ was supported by the initial trial results, admittedly those being due to a serendipitous mess up of their trial.
I don't often disagree with you LL, but I think half assed isn't the right way to put it. The UK took a huge chance but it was based on what was already known about vaccines and how we generally react to them. We've got most things wrong during the pandemic no doubt, but I think the dosage strategy was an informed, calculated risk.
 
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