Chris O'Connor
Player Valuation: £35m
You think they’ll be a variant more deadly than the original virus that will completely evade the vaccine to such an extent it will cause mass death?
That’s some prediction, I must say. What’s your reasoning for this?
I mean, we all know variants are a danger, but they’re just the nature of this virus and it would surprise me to see mass deaths as the result of a new variant.
The methodology of all the current vaccines in use basically depend on the structure of just one of the proteins that exist on the surface of the Covid virus remaining largely intact.
Any protein has its own DNA and specific structure unique to that protein, so any mutations that significantly change that structure will in effect mean it will 'look different' and have a different 'shape'.
Currently the vaccines in production trigger the body to produce antibodies which will recognise the surface protein's current 'shape' and will therefore attack and destroy the virus which has that protein on its outer surface.
(antibodies are the body's natural defence mechanism - the body's naturally produced attack weapons against the virus if you like - the vaccines are currently successful because they induce the body to produce these antibodies specifically against the Covid virus's CURRENT surface protein 'shape' )
The South African and Brazilian mutations are so dangerous because they significantly change the 'shape' of the Covid virus's surface protein in more than one place on the protein. The body's vaccine induced defenders - their attack weapons - the before mentioned antibodies are looking for a particularly shaped protein but have difficulty recognising that protein if it's significantly changed it's 'shape', and therefore are far less effective in targeting the protein and subsequently killing the Covid virus which has the protein on its surface.
This may sound long winded but is simpler to demonstrate with pictures tbh but I've had to try and just use words.
The new generation of super vaccines being developed will not target that surface protein at all, so any change of 'shape' shouldn't matter, instead it will target a protein that exists within the core of the virus itself which is far less susceptible to changes from mutations than proteins sticking out on the surface of the virus. The super vaccines will therefore hopefully be far more resilient and lasting without having to be supplemented by boosters at a later date.
The work currently going in at Oxford envisages a timescale of something far less than a year before they're ready for production. With techniques and testing scenarios already in place it could be fast tracked through and ready for next January.