Given
Moyes' lack of trust in Yakubu and Beckford, I'd probably go with Cahill upfront, Rodwell just off him and Osman in the middle of the park, alongside Fellaini. They where developing a decent understanding before Fellaini's injury, and it gives us a bit more creativity, aswell as someone who's comfortable in possession.
You don't know what your going to get with Bilyaletdinov and Coleman, so we'll need that strong spine in central areas, and I really can't see us doing much with our one creative outlet (Osman, Bily) stuck in positions where they aren't going to consistently influence the game. With Arteta and Pienaar out, we are going to have to find the right balance.