Current Affairs Coronavirus Thread - Serious stuff !!!

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Pfizer we’re 90% in immoral clinical trial, Merck’s was 50% but has dropped to about 30% in further phase 3 trials.
Can knock a good 50% off that Pfizer figure in the real world I'd imagine if it's similar to some of their claims from 12 months ago...

I assume immoral was a typo but is a perfect word to associate with Pfizer
 
Can knock a good 50% off that Pfizer figure in the real world I'd imagine if it's similar to some of their claims from 12 months ago...

I assume immoral was a typo but is a perfect word to associate with Pfizer

Let’s hope not mate, tbh you always see a reduction in results from clinical to real world, largely based on the environment the clinical trial takes place in can’t replicate the real rigours of the real world and the multitude of different variables that impact.

Still with this drug the independent observers recommended stopping the trial early, that’s a very encouraging sign, it’s usually done when a new treatment is showing such a positive result that it’s becomes unethical to continue at the same pace, as it could do more good fast tracking the process - usually based on very good and massively compeling results.

It was a typo, but funny I was listening to an African professor early, they were talking about the unfair restrictions placed on Africa due to Omicron, it’s increasingly likely Africa may not have been the Origen, while other countries have had cases but not the same restrictions.

She spoke about how Omicron could be attributed to the greed of the Western World using their wealth to double, triple vaccinate with the vast majority of the world unvaccinated and that this and other variants are inevitable, when it was put to her about Covax.

She said that much of the vaccinations being donated are vaccines that may have a month or weeks to their expiry, that put services in Africa under massive pressure that are already under developed, with huge geographical vastness and rural areas that don’t have the technology in terms of communication that we do in the west.

In short she essentially put forward that Africa and the developing world is/has been prejudiced by the reaction of Omicron in comparrison to other countries, by vaccine access and the inevitable outcome is more Omnicron’s as we go on.

She made a compelling case that maybe our focus needs to go more towards the unvaccinated in the developing workd now as opposed to vaccine hoarding and multiple boosters in the west. Perhaps it’s the best way to end the variant hamster wheel we seem to be on. Morality, Covid and self preservation are probably thing all stake holders should reflect on in terms of next steps.
 
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Dreading the scene tomorrow in work, hoping there won’t be any kick offs as we’ve been told that the store hasn’t worked out how to govern the new mask guidelines other than it’s compulsory for staff bar a valid reason, technically I can class my asthma as a reason not to but I’m not that selfish so will be wearing a mask from leaving home for the bus to arriving home, only switching once I’m in work from my own personal one to a blue surgical one as it’s lighter and easier to breathe/speak in
 
Dreading the scene tomorrow in work, hoping there won’t be any kick offs as we’ve been told that the store hasn’t worked out how to govern the new mask guidelines other than it’s compulsory for staff bar a valid reason, technically I can class my asthma as a reason not to but I’m not that selfish so will be wearing a mask from leaving home for the bus to arriving home, only switching once I’m in work from my own personal one to a blue surgical one as it’s lighter and easier to breathe/speak in
Hope it all goes smoothly mate x
 
It is unfortunately.

On the plus side their vaccination rate is a bit higher (although lower than many other European nations) so hopefully that helps with hospitalizations but the lack of the earlier waves is going to also mean less natural immunity in the unvaccinated.

Unfortnately I think you are right, Austria is similar, though they’ve put very strict restrictions in place. A huge disadvantage in this in central Europe is its interconnectedness, I know we talk about countries all the time, but when you look at the geographical region, of Germany, Netherlands, Belgium, Czech R. and Austria, the whole region is going through largely the same wave profile and partly because they all share borders and the moving between countries. They are incredible figures from Germany though, I’m shocked by them.
 
It is unfortunately.

On the plus side their vaccination rate is a bit higher (although lower than many other European nations) so hopefully that helps with hospitalizations but the lack of the earlier waves is going to also mean less natural immunity in the unvaccinated.

Just looking there mate, the U.K. had incredibly had 1 more Covid case then Germany today, population of Germany is 83 million, population of U.K. is 67 million.

So the U.K. would actually be higher than Germany on that chart, and in comparison with the USA close to 4 times as many cases as the USA.

That said the curve would be flatter and we wouldn’t see that alarming spike we are seeing in Germany. It’s the exponential growth rate really that’s the huge concern. The U.K. have a better vaccine profile to.

You'd wonder about Omicron, that’s incredible growth, while we can say with a decent amount of certainty at this stage that Omicron is far more transmissible than Delta.
 

The study provides real-world evidence that the vaccine was highly protective against hospitalization among adolescents even as the Delta variant (B.1.617.2) became the predominant strain. The highly transmissible SARS-CoV-2 variant contributed to a surge in pediatric hospitalizations over the summer and into the early fall. Previously, a clinical trial showed the vaccine was 100% effective against symptomatic COVID-19 among individuals aged 12 to 15 years.

The new study involved 179 individuals aged 12 to 18 years hospitalized for laboratory-confirmed COVID-19 and a control group of 285 adolescents hospitalized for other causes between June and September 2021. It excluded partially vaccinated individuals.

Vaccination coverage was 3% in the COVID-19 group and 33% in the control group. Six vaccinated patients were hospitalized for COVID-19, and none were admitted to the intensive care unit (ICU) or died. In contrast, 173 unvaccinated patients were hospitalized for COVID-19, 77 were admitted to ICUs, and 29 required life support, including 2 who died. Unvaccinated patients with COVID-19 stayed a median of 5 days in the hospital, 2 days longer than their vaccinated peers with the illness.
 
Just looking there mate, the U.K. had incredibly had 1 more Covid case then Germany today, population of Germany is 83 million, population of U.K. is 67 million.

So the U.K. would actually be higher than Germany on that chart, and in comparison with the USA close to 4 times as many cases as the USA.

That said the curve would be flatter and we wouldn’t see that alarming spike we are seeing in Germany. It’s the exponential growth rate really that’s the huge concern. The U.K. have a better vaccine profile to.

You'd wonder about Omicron, that’s incredible growth, while we can say with a decent amount of certainty at this stage that Omicron is far more transmissible than Delta.
All just educated guesswork at this point until we have larger data sets but found this whole thread interesting and follows on from similar musing that I posted earlier by Trevor Bedford

 
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