Carlo Ancelotti will be aiming to become the first Everton manager since David Moyes in 2007 to pick up three points at Vicarage Road on Saturday afternoon.
Everton won 3-0 and the Hornets were relegated that season but since their promotion in 2015 the Blues have had a torrid time.
2015/16 was as good as it got for Everton, a 1-1 draw that day, since then Watford picked up a 3-2 victory and two consecutive 1-0 wins.
Watford enjoyed a brilliant start to life under Nigel Pearson after he became their third permanent manager of the campaign, but recently it hasn’t been great.
They lost a relegation six pointer to Aston Villa last time out in the Premier League, before losing an FA Cup replay to League One Tranmere Rovers.
This will be the third meeting between the sides this season, Everton won 1-0 in the league and 2-0 in the Carabao Cup.
The Hornets start the weekend in the drop zone but could go as high as 15th with a win over Everton.
On the other hand, a win with a massive goal swing could see Everton overtake Sheffield United who currently sit in eighth place.
One to watch
Former Everton man Gerard Deulofeu will prove to be Watford’s main threat on Saturday.
His electric pace is enough to cause any defender a problem if he is at his best, the Spaniard has netted four goals this season and has picked up four assists.
The hosts will be without Daryl Janmaat, Kiko Femenia and Sebastian Prodl.
Tom Cleverley and Ismaila Sarr are doubts.
Everton will welcome Richarlison, Gylfi Sigurdsson and Alex Iwobi back into first team action after injury layoffs.
This will come a bit too soon for Andre Gomes, Jean-Philippe Gbamin is out.
Man in the middle
Craig Pawson will be in charge of the cards for this one.
In 21 games this season he has shown 95 yellow cards and two reds.