Current Affairs Coronavirus Thread - Serious stuff !!!

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davek said:
"But I have no medical training - I have no idea how big/small some of these factors would be so given a choice between you, me or the scientists I’m betting in the latter to know what they are talking about!"

But it's the peer review by scientists that flagged up the imbalance in demographic, not me.

I would urge you and others to read this article:

Bloomberg - Are you a robot?

www.bloomberg.com
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Well I read it and this seems like a relevant bit - as far as I’m aware these extra trials are taking place and, whilst noting limitations, the authors do say “hard not to be excited by the findings” which seems a long way from your “Oxford vaccine not what we need” statement
Further trials to substantiate the findings and an investigation of efficacy in older adults are needed, Maria Deloria Knoll and Chizoba Wonodi of the Johns Hopkins Bloomberg School of Public Health wrote in an article accompanying the data.

The authors noted “limitations” with the results, including less than 4% of participants who were older than 70 years of age, as well as the finding that no participants older than 55 received the mixed-dose regimen. Still, they said that the expected lower price of the vaccine holds promise for lower- and middle-income nations.

“Despite the outstanding questions and challenges in delivering these vaccines, it is hard not to be excited about these findings and the existence of three safe and efficacious Covid-19 vaccines,” they wrote.
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Blueclouds said:
This is getting me down, I'm constantly worrying about the vulnerable family members. Will this ever end
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Once we've vaccinated the elderly and vulnerable we should have eliminated the vast majority of hospitalisations and deaths. I think it's somewhere around 9 million to eliminate 70% of those admissions.

And then all the over 50s and vulnerable are done your looking at a 99% reduction of people hospitalised

I'm not sure any people should put up with restrictions after that has been achieved, when very very few people are ending up in hospital. So in essence can see the end myself...
 
Chewbacca said:
Yeah but we’re “Great” Britain. We do have government ministers telling the EU that we are a better country than them.
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Well the EU isn't a country, it's a trading block.

I have no issue with any country in the EU or Europe as a continent. The EU itself isn't something idyllic for me but that's by the by.

Our government are crap - we know this. But every government in Europe is doing the same thing atm. Germany have been one of the worst hit this time around, yet dealt with it better than anyone else in the spring.
 
LinekersLegs said:
Well I read it and this seems like a relevant bit - as far as I’m aware these extra trials are taking place and, whilst noting limitations, the authors do say “hard not to be excited by the findings” which seems a long way from your “Oxford vaccine not what we need” statement
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Yes, and that related to the general prospect of getting a higher than 70% efficacy for the overwhelmingly younger groups they used for participation in the low-high dosage trials. It doesn't say they were "excited" about the vaccine where older age groups were concerned.
 
davek said:
Yes, and that related to the general prospect of getting a higher than 70% efficacy for the overwhelmingly younger groups they used for participation in the low-high dosage trials. It doesn't say they were "excited" about the vaccine where older age groups were concerned.
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So I dug out their full article here

And to me they don’t seem to have concerns about the trial design or any indicatiion that results will be worse for older age groups, just that they would like some further testing to be confident.

I went and looked at some of the early data

and the follow ups that involved older groups
And there didn’t seem to be any flags about the elderly, in fact if anything the elderly seemed to have less side effects with no difference in antibody responses
Neutralising antibody titres after a boost dose were similar across all age groups (median MNA80 at day 42 in the standard-dose groups: 18–55 years, 193 [IQR 113–238], n=39; 56–69 years, 144 [119–347], n=20; and ≥70 years, 161 [73–323], n=47; p=0·40). By 14 days after the boost dose, 208 (>99%) of 209 boosted participants had neutralising antibody responses. T-cell responses peaked at day 14 after a single standard dose of ChAdOx1 nCoV-19 (18–55 years: median 1187 spot-forming cells [SFCs] per million peripheral blood mononuclear cells [IQR 841–2428], n=24; 56–69 years: 797 SFCs [383–1817], n=29; and ≥70 years: 977 SFCs [458–1914], n=48).

Interpretation​

ChAdOx1 nCoV-19 appears to be better tolerated in older adults than in younger adults and has similar immunogenicity across all age groups after a boost dose. Further assessment of the efficacy of this vaccine is warranted in all age groups and individuals with comorbidities.
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So with that Dave I am going to await the Phase 3 results and not get drawn into this discussion any further.

Wishing you and the family a pleasant Christmas.
 
LinekersLegs said:
So I dug out their full article here

And to me they don’t seem to have concerns about the trial design or any indicatiion that results will be worse for older age groups, just that they would like some further testing to be confident.

I went and looked at some of the early data

and the follow ups that involved older groups
And there didn’t seem to be any flags about the elderly, in fact if anything the elderly seemed to have less side effects with no difference in antibody responses

So with that Dave I am going to await the Phase 3 results and not get drawn into this discussion any further.

Wishing you and the family a pleasant Christmas.
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And to you and yours!
 
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