I'd go 4-1-3-2
Pickford
Kenny - Keane - Holgate - Baines
Gana
Davies - Rooney - Sigurdsson
Sandro - Mirallas
Bench is Stek, Cuco, Jags, Schneiderlin, Klaassen, Lookman, DCL.
Easy to switch between this, a 4-3-3 and a diamond midfield as the in-game situations demand. Tell Kenny and Baines to defend first and foremost - there are plenty of players in front of them who are capable ball-carriers so just give them the ball rather than trying to move forward and create from the fullback positions. The removal of Williams AND Jags from the starting lineup allows the back four to play a higher line. We don't need two defensive midfielders, especially when one of them (Schneiderlin) doesn't currently bother tracking runners. Sandro and Mirallas give us pace up front, which should help to force opponents to play deeper back lines - this in turn should allow Davies, Rooney and Sigurdsson more space and fewer opposing players in close proximity to them. Davies and Sigurdsson can drop back either side of Gana to help when needed.
Pick the same lineup for Sunderland, Bournemouth, Limassol and Burnley. Yes it's four games in eleven days, but we really should be looking to have two of them (Sunderland and Limassol) done and dusted at half-time, and using our substitutes to rest key players. And after the Burnley fixture there's a two-week break. one thing that has definitely nOT helped us recently is the constant chopping and changing of personnel.