Current Affairs Coronavirus Thread - Serious stuff !!!

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Just had my first. Was given Pfizer. Did anyone to get side effects with this one?
Congrats!

Side effects for first dose seem to depend a lot on whether you were previously exposed to COVID. Charts A and D are those of the side effects to Pfizer first dose recorded in a large UK study, B and E for second dose. Good news is that even if you get them they don’t typically last very long.
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Figure 1Proportion of participants self-reporting adverse effects to the COVID Symptom Study app within 8 days after vaccination
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The top row shows systemic effects and the bottom row shows local effects within 8 days after receipt of the first dose (A, D) or second dose (B, E) of the BNT162b2 vaccine or the first dose of the ChAdOx1 nCoV-19 vaccine (C, F). Shading indicates 95% CIs.

Given preliminary evidence from small studies21, 22, 23 suggesting that reactogenicity is higher among individuals previously infected with SARS-CoV-2, we investigated the extent to which previous SARS-CoV-2 infection (based on self-reported previous positive PCR or lateral flow result) was associated with reports of adverse effects.

Individuals vaccinated with a single dose of BNT162b2 were more likely to report systemic effects if they had a previous SARS-CoV-2 positive test than were those without known past infection (5148 [35·8%] of 14 369 vs 33 007 [12·3%] of 267 734; OR 3·97 [95% CI 3·83–4·12], p<0·0001).
 

There are two ways a vaccine can reduce transmission risk. First, a vaccine may decrease the probability of a recipient becoming infected in the first place by protecting against both symptomatic (as measured by the primary endpoints of the clinical trials) and asymptomatic infection (which can only be identified using systematic PCR or serology testing).

Second, a vaccine may decrease the probability of secondary transmission from an infected vaccine recipient by reducing the duration or degree of infectiousness. Accumulating evidence suggests that SARS-CoV-2 vaccines can substantially reduce transmission through both of these mechanisms.
 
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