As Chico mentioned, with our tough run of games coming up we are going to have to rest some of our first team players soon - we don't want to risk Barry looking as tired as Gerrard did today. The ones who probably need a break the most are Baines, Coleman, McCarthy and Barry as they have the most physically demanding roles and we'll need them fresh if we want to play well in the derby. Naismith might also need a break as he played all through preseason and has a tendency to run himself into the ground.
I'd love us to win the league cup so I'd choose this game to rest a lot of them although I doubt that martinez will make so many changes in one go.