Everton Reserves take on Blackburn Rovers at Halton Stadium in Widnes on Tuesday evening.
Andy Holden's side have recorded two consecutive 1-1 draws in their last two FA Premier Reserve League North fixtures - against Liverpool and Bolton respectively, and will be looking to return to winning ways and collect all three points against tonight's visitors.
Injuries in the first team squad have had a knock-on effect and there are few household names in the second string side.
January signing Seamus Coleman is set to start alongside Moses Barnett, John Irving, James McCarten in defence, while James Wallace - an unused substitute for David Moyes' side against Middlesbrough on Sunday – is in the midfield.
Wallace is joined by Eunan O'Kane, Hope Akpan and John Paul Kissock, the latter getting a start after recently returning from a one-month loan spell at League Two side Accrington Stanley.
Kieran Agard and Jose Baxter will play up front while Iain Turner is in goal for the Toffees.
This will be the third meeting between the two Clubs in 6 days, as the under 18s recorded a comprehensive 3-1 victory away from home on Saturday, while the Senior squad had to settle for a share of the spoils in last week's Premier League encounter at Ewood Park.
The Blues’ second string sit one place behind Rovers in the league table in 6th, and in their last meeting, Everton suffered a 2-1 defeat away at Blackburn after an 88th minute second goal by Bryan Hodge back in November - a result the Toffees will certainly want to overturn in tonight's clash.
