I don't think there was much wrong with him playing against Palace (well, there was in the situation of the game, mind) but in general, him being available etc.
But it's after that - that's the key bit. It might've been 15 mins, but as you say, it's all the stuff working up to that, then the body adjusting to playing and recovering from that. Bit like when Seamus came back from his leg-break, played one game at full pelt, then was out for a week or two to give his body time to fully recover and the adrenaline out of his system.
He may well have been given that time, and it's just bad luck. But the amount of strain his body will have gone through... he was always going to be susceptible. Which is why someone diving in on him is also completely daft.