I think from a businesses perspective, looking to locate in the North, Manchester would probably be number 1 choice, it has a bigger airport with more international flights and better rail, tram and motorway links than the other Northern cities
Liverpool would need major infrastructure investment to be a viable alternative.
That's the kind of thing the government has to instigate, big scale infrastructure investment, to try to move some businesses away from London, to spread the wealth a little and stop the North/south divide from increasing.
However most political parties shy away from this sort of thing because it takes time to implement and costs lots of money and doesn't win votes at the next election.
So they will probably just; take a penny off beer, wine and Whisky in the next budget (& put 3p on fuel!)