Think you have to look at more than one game at a time, so:
@Atalanta:
Pickford
Kenny Keane Williams Martina
Besic Davies
Lennon Klaassen Siggy
Sandro
@Man U:
Pickford
Holgate Keane Jags Baines
Gana Schneiderlin
Lookman Rooney Siggy
DCL
Agree with the principle, but the Atlanta game is far too important to play a second string.
Needs to be a mix